MIR4323

Summary

MIR4323 (microRNA 4323, HGNC:38394) is a microRNA gene on chromosome 19q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422980 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38394
Approved symbol	MIR4323
Name	microRNA 4323
Location	19q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4323
Ensembl gene	ENSG00000266226
Ensembl biotype	miRNA
Entrez	100422980
RNAcentral	URS000075A9C4 — ncRNA, 69 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582929

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582929 — 1 exons

Exon	Start	End
ENSE00002711016	42133445	42133513

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 88.60.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	88.60	gold quality
vermiform appendix	UBERON:0001154	84.10	gold quality
blood	UBERON:0000178	78.18	gold quality
muscle of leg	UBERON:0001383	77.52	gold quality
monocyte	CL:0000576	75.35	gold quality
endometrium	UBERON:0001295	73.67	gold quality
substantia nigra	UBERON:0002038	72.58	gold quality
heart left ventricle	UBERON:0002084	72.33	gold quality
granulocyte	CL:0000094	72.19	gold quality
urinary bladder	UBERON:0001255	70.02	gold quality
lymph node	UBERON:0000029	69.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.44	gold quality
omental fat pad	UBERON:0010414	68.94	gold quality
gastrocnemius	UBERON:0001388	68.32	gold quality
multicellular organism	UBERON:0000468	68.24	gold quality
adult mammalian kidney	UBERON:0000082	67.85	gold quality
ascending aorta	UBERON:0001496	67.16	gold quality
thoracic aorta	UBERON:0001515	67.07	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.90	gold quality
liver	UBERON:0002107	66.66	gold quality
body of stomach	UBERON:0001161	66.32	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.15	gold quality
spleen	UBERON:0002106	66.02	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.78	gold quality
skin of leg	UBERON:0001511	65.16	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.96	gold quality
prostate gland	UBERON:0002367	64.48	gold quality
right frontal lobe	UBERON:0002810	63.74	gold quality
anterior cingulate cortex	UBERON:0009835	63.62	gold quality
transverse colon	UBERON:0001157	63.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• when the miRNA miR 4323 was overexpressed under cyclic hydrodynamic pressure, LYN is decreased and the Erk1/2 signaling pathway is activated; in addition, miR 4323 is involved in human bladder smooth muscle cell proliferation when under hydrodynamic pressure. (PMID:27651435)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.