MIR4324

Summary

MIR4324 (microRNA 4324, HGNC:38392) is a microRNA gene on chromosome 19q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422979 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38392
Approved symbol	MIR4324
Name	microRNA 4324
Location	19q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4324
Ensembl gene	ENSG00000265407
Ensembl biotype	miRNA
Entrez	100422979
RNAcentral	URS000075C737 — miRNA, 72 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584846

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584846 — 1 exons

Exon	Start	End
ENSE00002703030	49308797	49308868

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 84.02.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	84.02	gold quality
bone marrow	UBERON:0002371	82.92	gold quality
right coronary artery	UBERON:0001625	79.46	gold quality
blood	UBERON:0000178	78.13	gold quality
tonsil	UBERON:0002372	78.03	gold quality
lymph node	UBERON:0000029	77.87	gold quality
endometrium	UBERON:0001295	77.07	gold quality
placenta	UBERON:0001987	76.24	gold quality
rectum	UBERON:0001052	76.05	gold quality
right ovary	UBERON:0002118	75.91	gold quality
body of pancreas	UBERON:0001150	75.73	gold quality
pancreas	UBERON:0001264	75.68	gold quality
smooth muscle tissue	UBERON:0001135	75.51	gold quality
monocyte	CL:0000576	75.05	gold quality
leukocyte	CL:0000738	74.90	gold quality
ovary	UBERON:0000992	74.22	gold quality
liver	UBERON:0002107	74.16	gold quality
islet of Langerhans	UBERON:0000006	73.63	gold quality
left ovary	UBERON:0002119	73.52	gold quality
muscle of leg	UBERON:0001383	73.21	gold quality
mucosa of stomach	UBERON:0001199	73.14	gold quality
urinary bladder	UBERON:0001255	72.98	gold quality
gastrocnemius	UBERON:0001388	72.97	gold quality
adult mammalian kidney	UBERON:0000082	72.58	gold quality
right adrenal gland	UBERON:0001233	72.55	gold quality
right lung	UBERON:0002167	72.29	gold quality
right lobe of liver	UBERON:0001114	72.20	gold quality
granulocyte	CL:0000094	72.17	gold quality
myometrium	UBERON:0001296	72.15	gold quality
popliteal artery	UBERON:0002250	71.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• In miRNA activity assays using the full-length hap.01 and hap.08 3’-UTR reporter vectors and follow-up validation experiments, hsa-miR-4324 and hsa-miR-4756-5p significantly reduced huntingtin gene (HTT) 3’-UTR reporter activity and endogenous HTT protein levels. (PMID:31296921)
• miR-4324 inhibits ovarian cancer progression by targeting FEN1. (PMID:35246224)
• [Expression of miR-4324 and its targeted gene Talin2 in breast cancer]. (PMID:36329586)
• LINC01002 functions as a ceRNA to regulate FRMD8 by sponging miR-4324 for the development of COVID-19. (PMID:38734674)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.