MIR4325

Summary

MIR4325 (microRNA 4325, HGNC:38304) is a microRNA gene on chromosome 20q13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422883 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38304
Approved symbol	MIR4325
Name	microRNA 4325
Location	20q13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4325
Ensembl gene	ENSG00000266666
Ensembl biotype	miRNA
Entrez	100422883
RNAcentral	URS000075D040 — ncRNA, 90 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583049

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583049 — 1 exons

Exon	Start	End
ENSE00002722272	57321502	57321591

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 67.63.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of uterus	UBERON:0009853	67.63	gold quality
minor salivary gland	UBERON:0001830	65.92	gold quality
thyroid gland	UBERON:0002046	65.90	gold quality
lung	UBERON:0002048	64.46	gold quality
caudate nucleus	UBERON:0001873	64.23	gold quality
skin of abdomen	UBERON:0001416	54.56	gold quality
colon	UBERON:0001155	48.39	gold quality
testis	UBERON:0000473	46.95	gold quality
left testis	UBERON:0004533	46.69	gold quality
right testis	UBERON:0004534	43.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.