MIR4326

Summary

MIR4326 (microRNA 4326, HGNC:38314) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422945 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38314
Approved symbol	MIR4326
Name	microRNA 4326
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4326
Ensembl gene	ENSG00000266104
Ensembl biotype	miRNA
Entrez	100422945
RNAcentral	URS000075D5DA — miRNA, 59 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582203

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582203 — 1 exons

Exon	Start	End
ENSE00002696537	63286808	63286866

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 88.30.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	88.30	gold quality
duodenum	UBERON:0002114	84.83	gold quality
bone marrow	UBERON:0002371	83.60	gold quality
endometrium	UBERON:0001295	82.08	gold quality
adrenal tissue	UBERON:0018303	81.86	gold quality
apex of heart	UBERON:0002098	81.80	gold quality
placenta	UBERON:0001987	81.57	gold quality
pituitary gland	UBERON:0000007	80.06	gold quality
mucosa of transverse colon	UBERON:0004991	79.76	gold quality
blood	UBERON:0000178	79.28	gold quality
adenohypophysis	UBERON:0002196	78.42	gold quality
lymph node	UBERON:0000029	78.36	gold quality
right uterine tube	UBERON:0001302	78.31	gold quality
monocyte	CL:0000576	78.02	gold quality
calcaneal tendon	UBERON:0003701	77.68	gold quality
ectocervix	UBERON:0012249	77.51	gold quality
transverse colon	UBERON:0001157	76.99	gold quality
fundus of stomach	UBERON:0001160	76.70	gold quality
muscle of leg	UBERON:0001383	76.67	gold quality
metanephros cortex	UBERON:0010533	76.59	gold quality
stomach	UBERON:0000945	76.52	gold quality
body of stomach	UBERON:0001161	76.49	gold quality
body of pancreas	UBERON:0001150	76.32	gold quality
smooth muscle tissue	UBERON:0001135	76.27	gold quality
pancreas	UBERON:0001264	76.25	gold quality
tonsil	UBERON:0002372	76.24	gold quality
liver	UBERON:0002107	76.22	gold quality
spleen	UBERON:0002106	76.02	gold quality
right lobe of liver	UBERON:0001114	75.93	gold quality
left uterine tube	UBERON:0001303	75.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• double knockdown of APC2 and miR-4326 promoted lung cancer cell proliferation, confirming that miR-4326 promoted lung cancer cell proliferation by inhibiting APC2. (PMID:29101731)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.