MIR4418

Summary

MIR4418 (microRNA 4418, HGNC:41789) is a microRNA gene on chromosome 1p36.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616433 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41789
Approved symbol	MIR4418
Name	microRNA 4418
Location	1p36.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4418
Ensembl gene	ENSG00000266564
Ensembl biotype	miRNA
Entrez	100616433
RNAcentral	URS000075C3AB — miRNA, 62 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581169

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581169 — 1 exons

Exon	Start	End
ENSE00002694821	22266239	22266300

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 92.44.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	92.44	gold quality
muscle of leg	UBERON:0001383	82.04	gold quality
gastrocnemius	UBERON:0001388	74.00	gold quality
monocyte	CL:0000576	73.00	gold quality
spleen	UBERON:0002106	72.79	gold quality
blood	UBERON:0000178	68.53	gold quality
tibial artery	UBERON:0007610	67.36	gold quality
right adrenal gland cortex	UBERON:0035827	67.13	gold quality
skin of abdomen	UBERON:0001416	67.01	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.58	gold quality
left adrenal gland	UBERON:0001234	65.94	gold quality
skin of leg	UBERON:0001511	65.80	gold quality
transverse colon	UBERON:0001157	65.43	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.32	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.96	gold quality
substantia nigra	UBERON:0002038	63.87	gold quality
left testis	UBERON:0004533	44.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.