MIR4420

Summary

MIR4420 (microRNA 4420, HGNC:41772) is a microRNA gene on chromosome 1p35.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616164 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41772
Approved symbol	MIR4420
Name	microRNA 4420
Location	1p35.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4420
Ensembl gene	ENSG00000264773
Ensembl biotype	miRNA
Entrez	100616164
RNAcentral	URS000075AB16 — ncRNA, 77 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583944

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583944 — 1 exons

Exon	Start	End
ENSE00002693183	30739156	30739232

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 98.05.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	98.05	gold quality
vermiform appendix	UBERON:0001154	93.07	gold quality
monocyte	CL:0000576	92.43	gold quality
blood	UBERON:0000178	91.19	gold quality
tonsil	UBERON:0002372	90.54	gold quality
granulocyte	CL:0000094	85.62	gold quality
spleen	UBERON:0002106	83.92	gold quality
right lung	UBERON:0002167	83.89	gold quality
lymph node	UBERON:0000029	83.37	gold quality
upper lobe of left lung	UBERON:0008952	82.05	gold quality
lung	UBERON:0002048	81.98	gold quality
placenta	UBERON:0001987	80.55	gold quality
smooth muscle tissue	UBERON:0001135	78.78	gold quality
rectum	UBERON:0001052	78.59	gold quality
left uterine tube	UBERON:0001303	78.04	gold quality
small intestine	UBERON:0002108	77.84	gold quality
small intestine Peyer’s patch	UBERON:0003454	77.79	gold quality
descending thoracic aorta	UBERON:0002345	77.60	gold quality
gall bladder	UBERON:0002110	77.56	gold quality
omental fat pad	UBERON:0010414	77.30	gold quality
liver	UBERON:0002107	77.13	gold quality
adipose tissue	UBERON:0001013	76.60	gold quality
subcutaneous adipose tissue	UBERON:0002190	75.82	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.36	gold quality
thoracic aorta	UBERON:0001515	75.11	gold quality
right atrium auricular region	UBERON:0006631	75.09	gold quality
ascending aorta	UBERON:0001496	74.97	gold quality
tibial nerve	UBERON:0001323	74.75	gold quality
left coronary artery	UBERON:0001626	74.43	gold quality
multicellular organism	UBERON:0000468	74.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.