MIR4421

Summary

MIR4421 (microRNA 4421, HGNC:41879) is a microRNA gene on chromosome 1p32.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616189 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41879
Approved symbol	MIR4421
Name	microRNA 4421
Location	1p32.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4421
Ensembl gene	ENSG00000265538
Ensembl biotype	miRNA
Entrez	100616189
RNAcentral	URS000075E47B — ncRNA, 69 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578133

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578133 — 1 exons

Exon	Start	End
ENSE00002715236	51059837	51059905

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 83.66.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	83.66	gold quality
vermiform appendix	UBERON:0001154	83.50	gold quality
muscle of leg	UBERON:0001383	77.80	gold quality
urinary bladder	UBERON:0001255	77.54	gold quality
smooth muscle tissue	UBERON:0001135	77.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.12	gold quality
gastrocnemius	UBERON:0001388	74.72	gold quality
islet of Langerhans	UBERON:0000006	73.21	gold quality
putamen	UBERON:0001874	71.93	gold quality
blood	UBERON:0000178	71.61	gold quality
substantia nigra	UBERON:0002038	70.83	gold quality
heart	UBERON:0000948	70.48	gold quality
heart left ventricle	UBERON:0002084	69.93	gold quality
body of stomach	UBERON:0001161	69.79	gold quality
right atrium auricular region	UBERON:0006631	69.75	gold quality
right ovary	UBERON:0002118	69.65	gold quality
right lobe of thyroid gland	UBERON:0001119	68.93	gold quality
brain	UBERON:0000955	68.42	gold quality
adipose tissue	UBERON:0001013	68.00	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.92	gold quality
fallopian tube	UBERON:0003889	67.85	gold quality
body of pancreas	UBERON:0001150	67.68	gold quality
tibial artery	UBERON:0007610	67.68	gold quality
gall bladder	UBERON:0002110	67.39	gold quality
endometrium	UBERON:0001295	67.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.01	gold quality
left coronary artery	UBERON:0001626	66.93	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.90	gold quality
omental fat pad	UBERON:0010414	66.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Overexpression of miR-4421, trophoblast proliferation was significantly inhibited and cell cycle was significantly blocked. Luciferase reporter assay and Western blot showed that CYP11B2 can be served as a target gene of miR-4421. (PMID:29630094)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.