MIR4423

Summary

MIR4423 (microRNA 4423, HGNC:41784) is a microRNA gene on chromosome 1p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616481 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41784
Approved symbol	MIR4423
Name	microRNA 4423
Location	1p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4423
Ensembl gene	ENSG00000266110
Ensembl biotype	miRNA
Entrez	100616481
RNAcentral	URS000075CEC2 — miRNA, 80 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580922

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580922 — 1 exons

Exon	Start	End
ENSE00002703092	85133794	85133873

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 80.72.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
myometrium	UBERON:0001296	80.72	gold quality
adrenal tissue	UBERON:0018303	80.44	gold quality
blood	UBERON:0000178	78.07	gold quality
heart left ventricle	UBERON:0002084	75.90	gold quality
gastrocnemius	UBERON:0001388	75.64	gold quality
kidney	UBERON:0002113	74.27	gold quality
fallopian tube	UBERON:0003889	73.49	gold quality
islet of Langerhans	UBERON:0000006	73.06	gold quality
heart	UBERON:0000948	72.88	gold quality
calcaneal tendon	UBERON:0003701	72.80	gold quality
adult mammalian kidney	UBERON:0000082	72.17	gold quality
adrenal gland	UBERON:0002369	71.67	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.40	gold quality
left adrenal gland	UBERON:0001234	70.57	gold quality
left adrenal gland cortex	UBERON:0035825	70.57	gold quality
right atrium auricular region	UBERON:0006631	69.73	gold quality
endometrium	UBERON:0001295	69.11	gold quality
right uterine tube	UBERON:0001302	68.99	gold quality
gall bladder	UBERON:0002110	68.07	gold quality
fundus of stomach	UBERON:0001160	68.00	gold quality
right adrenal gland	UBERON:0001233	67.89	gold quality
stomach	UBERON:0000945	67.69	gold quality
tibial artery	UBERON:0007610	67.60	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.28	gold quality
body of uterus	UBERON:0009853	67.05	gold quality
lung	UBERON:0002048	67.00	gold quality
right adrenal gland cortex	UBERON:0035827	66.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.33	gold quality
ascending aorta	UBERON:0001496	66.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis. (PMID:34696684)
• Hepatitis C Virus Infection Cycle-Specific MicroRNA Profiling Reveals Stage-Specific miR-4423-3p Targets RIG-I to Facilitate Infection. (PMID:35402303)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.