MIR4424

Summary

MIR4424 (microRNA 4424, HGNC:41805) is a microRNA gene on chromosome 1q25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616328 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41805
Approved symbol	MIR4424
Name	microRNA 4424
Location	1q25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4424
Ensembl gene	ENSG00000266417
Ensembl biotype	miRNA
Entrez	100616328
RNAcentral	URS000075CF8C — ncRNA, 86 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585257

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585257 — 1 exons

Exon	Start	End
ENSE00002720228	178677749	178677834

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 79.58.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	79.58	gold quality
corpus callosum	UBERON:0002336	78.98	gold quality
monocyte	CL:0000576	76.70	gold quality
endometrium	UBERON:0001295	74.79	gold quality
blood	UBERON:0000178	74.76	gold quality
heart	UBERON:0000948	71.57	gold quality
gastrocnemius	UBERON:0001388	71.43	gold quality
body of stomach	UBERON:0001161	70.84	gold quality
right atrium auricular region	UBERON:0006631	70.31	gold quality
lung	UBERON:0002048	69.06	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.96	gold quality
amygdala	UBERON:0001876	67.40	gold quality
esophagus mucosa	UBERON:0002469	67.01	gold quality
liver	UBERON:0002107	66.97	gold quality
tibial artery	UBERON:0007610	66.57	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.53	gold quality
skin of abdomen	UBERON:0001416	65.96	gold quality
transverse colon	UBERON:0001157	65.71	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.65	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.48	gold quality
colon	UBERON:0001155	64.92	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.75	gold quality
skin of leg	UBERON:0001511	63.73	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.71	gold quality
omental fat pad	UBERON:0010414	63.31	gold quality
stomach	UBERON:0000945	63.15	gold quality
urinary bladder	UBERON:0001255	63.05	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.96	gold quality
brain	UBERON:0000955	62.94	gold quality
nucleus accumbens	UBERON:0001882	62.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.