MIR4425

Summary

MIR4425 (microRNA 4425, HGNC:41891) is a microRNA gene on chromosome 1p36.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616365 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41891
Approved symbol	MIR4425
Name	microRNA 4425
Location	1p36.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4425
Ensembl gene	ENSG00000264371
Ensembl biotype	miRNA
Entrez	100616365
RNAcentral	URS000075A0D6 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580572

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580572 — 1 exons

Exon	Start	End
ENSE00002705760	25023503	25023586

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 72.23.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	72.23	gold quality
blood	UBERON:0000178	70.90	gold quality
tonsil	UBERON:0002372	69.21	gold quality
granulocyte	CL:0000094	68.47	gold quality
lung	UBERON:0002048	68.41	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.77	gold quality
transverse colon	UBERON:0001157	66.62	gold quality
gall bladder	UBERON:0002110	66.37	gold quality
minor salivary gland	UBERON:0001830	64.54	gold quality
ascending aorta	UBERON:0001496	64.01	gold quality
body of stomach	UBERON:0001161	62.70	gold quality
spleen	UBERON:0002106	58.67	gold quality
skin of leg	UBERON:0001511	57.80	gold quality
upper lobe of left lung	UBERON:0008952	57.52	gold quality
right frontal lobe	UBERON:0002810	54.88	gold quality
cerebellar hemisphere	UBERON:0002245	53.95	gold quality
left testis	UBERON:0004533	41.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.