MIR4426

Summary

MIR4426 (microRNA 4426, HGNC:41848) is a microRNA gene on chromosome 1q31.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616345 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41848
Approved symbol	MIR4426
Name	microRNA 4426
Location	1q31.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4426
Ensembl gene	ENSG00000283795
Ensembl biotype	miRNA
Entrez	100616345
RNAcentral	URS000075B33C — miRNA, 63 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000640330

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000640330 — 1 exons

Exon	Start	End
ENSE00003803599	192716328	192716390

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 76.65.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	76.65	gold quality
spleen	UBERON:0002106	72.01	gold quality
gastrocnemius	UBERON:0001388	71.14	gold quality
hypothalamus	UBERON:0001898	70.49	gold quality
blood	UBERON:0000178	69.93	gold quality
Ammon’s horn	UBERON:0001954	69.38	gold quality
adult mammalian kidney	UBERON:0000082	68.15	gold quality
right frontal lobe	UBERON:0002810	68.00	gold quality
nucleus accumbens	UBERON:0001882	67.70	gold quality
heart left ventricle	UBERON:0002084	67.60	gold quality
body of pancreas	UBERON:0001150	67.17	gold quality
body of stomach	UBERON:0001161	67.02	gold quality
fundus of stomach	UBERON:0001160	66.69	gold quality
anterior cingulate cortex	UBERON:0009835	66.21	gold quality
left adrenal gland	UBERON:0001234	66.09	gold quality
transverse colon	UBERON:0001157	64.04	gold quality
amygdala	UBERON:0001876	63.77	gold quality
tibial artery	UBERON:0007610	63.50	gold quality
thoracic aorta	UBERON:0001515	63.42	gold quality
minor salivary gland	UBERON:0001830	62.83	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.06	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.58	gold quality
ascending aorta	UBERON:0001496	61.33	gold quality
endocervix	UBERON:0000458	61.28	gold quality
left lobe of thyroid gland	UBERON:0001120	60.79	gold quality
left coronary artery	UBERON:0001626	60.61	gold quality
right atrium auricular region	UBERON:0006631	60.60	gold quality
esophagus	UBERON:0001043	60.43	gold quality
adenohypophysis	UBERON:0002196	60.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• circ0000069 promotes cervical cancer cell proliferation and migration by inhibiting miR-4426. (PMID:33725572)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.