MIR4427

Summary

MIR4427 (microRNA 4427, HGNC:41678) is a microRNA gene on chromosome 1q42.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616390 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41678
Approved symbol	MIR4427
Name	microRNA 4427
Location	1q42.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4427
Ensembl gene	ENSG00000265744
Ensembl biotype	miRNA
Entrez	100616390
RNAcentral	URS000075F116 — miRNA, 68 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585213

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585213 — 1 exons

Exon	Start	End
ENSE00002713394	233624152	233624219

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 82.60.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	82.60	gold quality
blood	UBERON:0000178	79.63	gold quality
endometrium	UBERON:0001295	76.84	gold quality
kidney	UBERON:0002113	76.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.12	gold quality
stomach	UBERON:0000945	75.71	gold quality
islet of Langerhans	UBERON:0000006	73.30	gold quality
Ammon’s horn	UBERON:0001954	72.31	gold quality
body of stomach	UBERON:0001161	72.22	gold quality
adenohypophysis	UBERON:0002196	71.67	gold quality
heart left ventricle	UBERON:0002084	71.09	gold quality
liver	UBERON:0002107	70.81	gold quality
heart	UBERON:0000948	69.71	gold quality
urinary bladder	UBERON:0001255	69.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.20	gold quality
right atrium auricular region	UBERON:0006631	68.37	gold quality
right frontal lobe	UBERON:0002810	67.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.85	gold quality
skin of abdomen	UBERON:0001416	67.83	gold quality
body of pancreas	UBERON:0001150	67.27	gold quality
adult mammalian kidney	UBERON:0000082	67.08	gold quality
colon	UBERON:0001155	66.85	gold quality
body of uterus	UBERON:0009853	66.83	gold quality
vagina	UBERON:0000996	66.77	gold quality
cerebellar hemisphere	UBERON:0002245	66.72	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.60	gold quality
amygdala	UBERON:0001876	66.18	gold quality
transverse colon	UBERON:0001157	65.92	gold quality
intestine	UBERON:0000160	65.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.