MIR4428

Summary

MIR4428 (microRNA 4428, HGNC:41667) is a microRNA gene on chromosome 1q43.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616141 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41667
Approved symbol	MIR4428
Name	microRNA 4428
Location	1q43
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4428
Ensembl gene	ENSG00000266262
Ensembl biotype	miRNA
Entrez	100616141
RNAcentral	URS000075DF09 — miRNA, 73 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584884

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584884 — 1 exons

Exon	Start	End
ENSE00002695045	237471119	237471191

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 81.99.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0946 / max 21.5411, expressed in 33 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9290	0.0946	33

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	81.99	gold quality
monocyte	CL:0000576	77.86	gold quality
blood	UBERON:0000178	77.63	gold quality
right ovary	UBERON:0002118	75.42	gold quality
liver	UBERON:0002107	75.23	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.72	gold quality
gastrocnemius	UBERON:0001388	72.28	gold quality
heart left ventricle	UBERON:0002084	71.49	gold quality
heart	UBERON:0000948	71.48	gold quality
transverse colon	UBERON:0001157	70.56	gold quality
tibial artery	UBERON:0007610	70.21	gold quality
stomach	UBERON:0000945	70.07	gold quality
amygdala	UBERON:0001876	69.54	gold quality
right atrium auricular region	UBERON:0006631	69.10	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.15	gold quality
fundus of stomach	UBERON:0001160	68.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.91	gold quality
body of stomach	UBERON:0001161	66.68	gold quality
body of pancreas	UBERON:0001150	66.66	gold quality
hypothalamus	UBERON:0001898	66.45	gold quality
ascending aorta	UBERON:0001496	66.10	gold quality
esophagus mucosa	UBERON:0002469	65.84	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.75	gold quality
intestine	UBERON:0000160	65.29	gold quality
Ammon’s horn	UBERON:0001954	65.08	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.03	gold quality
skin of leg	UBERON:0001511	65.02	gold quality
body of uterus	UBERON:0009853	65.00	gold quality
zone of skin	UBERON:0000014	64.63	gold quality
lower esophagus	UBERON:0013473	64.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• serum miR-4428 and miR-4480 may be useful as biomarkers for predicting brain metastasis in patients with breast cancer. (PMID:31603918)
• Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary thyroid cancer via regulation of miR-4428/KLF9 axis. (PMID:38195623)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.