MIR4429

Summary

MIR4429 (microRNA 4429, HGNC:41579) is a microRNA gene on chromosome 2p25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616469 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41579
Approved symbol	MIR4429
Name	microRNA 4429
Location	2p25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4429
Ensembl gene	ENSG00000264010
Ensembl biotype	miRNA
Entrez	100616469
RNAcentral	URS000075EB92 — miRNA, 73 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580105

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580105 — 1 exons

Exon	Start	End
ENSE00002712980	11540605	11540677

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 85.31.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	85.31	gold quality
calcaneal tendon	UBERON:0003701	85.17	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.19	gold quality
heart	UBERON:0000948	78.34	gold quality
left ovary	UBERON:0002119	77.49	gold quality
ovary	UBERON:0000992	76.78	gold quality
monocyte	CL:0000576	75.56	gold quality
kidney	UBERON:0002113	74.57	gold quality
right ovary	UBERON:0002118	74.54	gold quality
liver	UBERON:0002107	73.19	gold quality
heart left ventricle	UBERON:0002084	72.95	gold quality
Ammon’s horn	UBERON:0001954	72.16	gold quality
gastrocnemius	UBERON:0001388	71.89	gold quality
lung	UBERON:0002048	71.57	gold quality
omental fat pad	UBERON:0010414	70.46	gold quality
adult mammalian kidney	UBERON:0000082	70.08	gold quality
right uterine tube	UBERON:0001302	69.90	gold quality
stomach	UBERON:0000945	69.68	gold quality
endometrium	UBERON:0001295	69.51	gold quality
right frontal lobe	UBERON:0002810	69.45	gold quality
myometrium	UBERON:0001296	69.09	gold quality
prostate gland	UBERON:0002367	68.63	gold quality
tibial artery	UBERON:0007610	68.62	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.32	gold quality
esophagus mucosa	UBERON:0002469	67.99	gold quality
intestine	UBERON:0000160	67.85	gold quality
fallopian tube	UBERON:0003889	67.48	gold quality
right lobe of liver	UBERON:0001114	67.02	gold quality
body of uterus	UBERON:0009853	66.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 16)

• LINC00313 acts as an oncogene in papillary thyroid cancer via sponging miR-4429 (PMID:29940766)
• Low miR-4429 expression is associated with Tumor Progression and Epithelial-Mesenchymal Transition in Clear Cell Renal Cell Carcinoma. (PMID:30844301)
• miR-4429 sensitized cervical cancer cells to irradiation by targeting RAD51. (PMID:31190335)
• miR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m(6)A-caused stabilization of SEC62 (PMID:31395342)
• SP1-DLEU1-miR-4429 feedback loop promotes cell proliferative and anti-apoptotic abilities in human glioblastoma. (PMID:31713587)
• MiR-4429 suppresses the malignant development of ovarian cancer by targeting YOD1. (PMID:32964960)
• LncRNA PSMA3-AS1 promotes colorectal cancer cell migration and invasion via regulating miR-4429. (PMID:33275226)
• MicroRNA-4429 suppresses proliferation of prostate cancer cells by targeting distal-less homeobox 1 and inactivating the Wnt/beta-catenin pathway. (PMID:33740948)
• microRNA-4429-5p suppresses the malignant development of colon cancer by targeting matrix metalloproteinase 16. (PMID:34448115)
• Circ_0067680 expedites the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells through miR-4429/CTNNB1/Wnt/beta-catenin pathway. (PMID:34649595)
• MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia. (PMID:34811713)
• Dysregulated circulating miR-4429 serves as a novel non-invasive biomarker and is correlated with EGFR mutation in patients with non-small cell lung cancer. (PMID:35167433)
• LINC00313/miR-4429 axis provides novel biomarkers for the diagnosis and prognosis of non-small cell lung cancer. (PMID:35485050)
• Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR4429/UBE2C axis. (PMID:35866591)
• CircABCA13 acts as a miR-4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1. (PMID:37017121)
• Exosomal circKIAA1797 Regulates Cell Progression and Glycolysis by Targeting miR-4429/PBX3 Pathway in Gastric Cancer. (PMID:37730964)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.