MIR4430

Summary

MIR4430 (microRNA 4430, HGNC:41646) is a microRNA gene on chromosome 2p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616136 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41646
Approved symbol	MIR4430
Name	microRNA 4430
Location	2p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4430
Ensembl gene	ENSG00000283591
Ensembl biotype	miRNA
Entrez	100616136
RNAcentral	URS000075C2DA — miRNA, 49 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636982

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636982 — 1 exons

Exon	Start	End
ENSE00003800396	33418516	33418564

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 77.60.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	77.60	gold quality
thoracic mammary gland	UBERON:0005200	70.12	gold quality
ascending aorta	UBERON:0001496	70.09	gold quality
esophagus mucosa	UBERON:0002469	68.79	gold quality
left ovary	UBERON:0002119	66.94	gold quality
caudate nucleus	UBERON:0001873	65.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.43	gold quality
tibial nerve	UBERON:0001323	65.26	gold quality
body of uterus	UBERON:0009853	63.77	gold quality
spleen	UBERON:0002106	62.93	gold quality
right testis	UBERON:0004534	58.06	gold quality
left testis	UBERON:0004533	47.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis. (PMID:32673063)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.