MIR4431

Summary

MIR4431 (microRNA 4431, HGNC:41738) is a microRNA gene on chromosome 2p16.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616431 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41738
Approved symbol	MIR4431
Name	microRNA 4431
Location	2p16.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4431
Ensembl gene	ENSG00000264975
Ensembl biotype	miRNA
Entrez	100616431
RNAcentral	URS000075D2EB — miRNA, 94 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579990

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579990 — 1 exons

Exon	Start	End
ENSE00002722302	52702522	52702615

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 76.97.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	76.97	gold quality
stomach	UBERON:0000945	76.02	gold quality
heart left ventricle	UBERON:0002084	73.73	gold quality
body of pancreas	UBERON:0001150	72.72	gold quality
monocyte	CL:0000576	71.60	gold quality
skin of abdomen	UBERON:0001416	66.89	gold quality
blood	UBERON:0000178	66.27	gold quality
skin of leg	UBERON:0001511	64.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.96	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.92	gold quality
right frontal lobe	UBERON:0002810	51.49	gold quality
left testis	UBERON:0004533	41.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.