MIR4432

Summary

MIR4432 (microRNA 4432, HGNC:41649) is a microRNA gene on chromosome 2p16.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616473 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41649
Approved symbol	MIR4432
Name	microRNA 4432
Location	2p16.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4432
Ensembl gene	ENSG00000266078
Ensembl biotype	miRNA
Entrez	100616473
RNAcentral	URS000075DF46 — ncRNA, 84 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581823

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581823 — 1 exons

Exon	Start	End
ENSE00002717362	60387362	60387445

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 80.66.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.66	gold quality
spleen	UBERON:0002106	76.42	gold quality
right atrium auricular region	UBERON:0006631	75.55	gold quality
monocyte	CL:0000576	71.79	gold quality
stomach	UBERON:0000945	68.73	gold quality
liver	UBERON:0002107	67.20	gold quality
skin of leg	UBERON:0001511	66.90	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.64	gold quality
right frontal lobe	UBERON:0002810	54.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.