MIR4433B

Summary

MIR4433B (microRNA 4433b, HGNC:50258) is a microRNA gene on chromosome 2p14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465833 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50258
Approved symbol	MIR4433B
Name	microRNA 4433b
Location	2p14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4433b
Ensembl gene	ENSG00000264297
Ensembl biotype	miRNA
Entrez	102465833
RNAcentral	URS0000759BCF — miRNA, 102 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581329

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581329 — 1 exons

Exon	Start	End
ENSE00002722254	64340747	64340848

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 79.46.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.46	gold quality
monocyte	CL:0000576	75.03	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.29	gold quality
adult mammalian kidney	UBERON:0000082	71.36	gold quality
adrenal tissue	UBERON:0018303	70.81	gold quality
tibial artery	UBERON:0007610	70.04	gold quality
stomach	UBERON:0000945	70.01	gold quality
heart left ventricle	UBERON:0002084	69.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.49	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.99	gold quality
right lobe of liver	UBERON:0001114	68.90	gold quality
left coronary artery	UBERON:0001626	68.70	gold quality
descending thoracic aorta	UBERON:0002345	68.11	gold quality
right ovary	UBERON:0002118	68.07	gold quality
skin of abdomen	UBERON:0001416	67.78	gold quality
caudate nucleus	UBERON:0001873	67.61	gold quality
hypothalamus	UBERON:0001898	67.52	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.51	gold quality
ascending aorta	UBERON:0001496	67.26	gold quality
transverse colon	UBERON:0001157	67.19	gold quality
prostate gland	UBERON:0002367	66.91	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.49	gold quality
adipose tissue	UBERON:0001013	66.45	gold quality
skin of leg	UBERON:0001511	66.29	gold quality
endometrium	UBERON:0001295	66.24	gold quality
tonsil	UBERON:0002372	65.93	gold quality
omental fat pad	UBERON:0010414	65.70	gold quality
esophagus mucosa	UBERON:0002469	65.51	gold quality
vagina	UBERON:0000996	65.41	gold quality
right atrium auricular region	UBERON:0006631	65.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.10

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.