MIR4434

Summary

MIR4434 (microRNA 4434, HGNC:41832) is a microRNA gene on chromosome 2p14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616419 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41832
Approved symbol	MIR4434
Name	microRNA 4434
Location	2p14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4434
Ensembl gene	ENSG00000283204
Ensembl biotype	miRNA
Entrez	100616419
RNAcentral	URS000075DA3E — miRNA, 53 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637066

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637066 — 1 exons

Exon	Start	End
ENSE00003796536	64525513	64525565

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 87.42.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	87.42	gold quality
bone marrow	UBERON:0002371	87.34	gold quality
granulocyte	CL:0000094	86.99	gold quality
kidney	UBERON:0002113	86.86	gold quality
adrenal tissue	UBERON:0018303	83.78	gold quality
adult mammalian kidney	UBERON:0000082	80.84	gold quality
vermiform appendix	UBERON:0001154	80.80	gold quality
blood	UBERON:0000178	80.66	gold quality
liver	UBERON:0002107	77.88	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.72	gold quality
calcaneal tendon	UBERON:0003701	77.58	gold quality
fundus of stomach	UBERON:0001160	77.01	gold quality
endometrium	UBERON:0001295	76.15	gold quality
stomach	UBERON:0000945	75.76	gold quality
islet of Langerhans	UBERON:0000006	75.22	gold quality
heart	UBERON:0000948	74.82	gold quality
left coronary artery	UBERON:0001626	72.85	gold quality
body of pancreas	UBERON:0001150	72.65	gold quality
gastrocnemius	UBERON:0001388	72.60	gold quality
heart left ventricle	UBERON:0002084	72.29	gold quality
Ammon’s horn	UBERON:0001954	72.21	gold quality
body of stomach	UBERON:0001161	72.09	gold quality
lung	UBERON:0002048	71.82	gold quality
right atrium auricular region	UBERON:0006631	71.61	gold quality
right lobe of liver	UBERON:0001114	70.77	gold quality
intestine	UBERON:0000160	70.74	gold quality
colon	UBERON:0001155	70.67	gold quality
tibial artery	UBERON:0007610	70.54	gold quality
right adrenal gland	UBERON:0001233	69.87	gold quality
skin of abdomen	UBERON:0001416	69.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.