MIR4436A

Summary

MIR4436A (microRNA 4436a, HGNC:41762) is a microRNA gene on chromosome 2p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616399 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41762
Approved symbol	MIR4436A
Name	microRNA 4436a
Location	2p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4436a
Ensembl gene	ENSG00000265510
Ensembl biotype	miRNA
Entrez	100616399
RNAcentral	URS000075BFC5 — miRNA, 85 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585278

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585278 — 1 exons

Exon	Start	End
ENSE00002692304	88812370	88812454

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 90.25.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	90.25	gold quality
monocyte	CL:0000576	75.19	gold quality
right testis	UBERON:0004534	74.73	gold quality
islet of Langerhans	UBERON:0000006	74.66	gold quality
lymph node	UBERON:0000029	74.26	gold quality
tonsil	UBERON:0002372	73.38	gold quality
ascending aorta	UBERON:0001496	73.36	gold quality
left testis	UBERON:0004533	72.85	gold quality
testis	UBERON:0000473	72.79	gold quality
blood	UBERON:0000178	72.51	gold quality
amygdala	UBERON:0001876	72.34	gold quality
fallopian tube	UBERON:0003889	70.89	gold quality
body of pancreas	UBERON:0001150	69.49	gold quality
stomach	UBERON:0000945	68.87	gold quality
right adrenal gland	UBERON:0001233	68.82	gold quality
body of stomach	UBERON:0001161	68.67	gold quality
transverse colon	UBERON:0001157	68.60	gold quality
endometrium	UBERON:0001295	68.35	gold quality
rectum	UBERON:0001052	68.08	gold quality
small intestine	UBERON:0002108	67.93	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.63	gold quality
colon	UBERON:0001155	67.59	gold quality
myometrium	UBERON:0001296	66.97	gold quality
right lobe of liver	UBERON:0001114	66.88	gold quality
left uterine tube	UBERON:0001303	66.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.60	gold quality
spleen	UBERON:0002106	66.15	gold quality
esophagus mucosa	UBERON:0002469	66.00	gold quality
nucleus accumbens	UBERON:0001882	65.68	gold quality
minor salivary gland	UBERON:0001830	65.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.