MIR4436B2

Summary

MIR4436B2 (microRNA 4436b-2, HGNC:43451) is a microRNA gene on chromosome 2q13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847033 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43451
Approved symbol	MIR4436B2
Name	microRNA 4436b-2
Location	2q13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4436b-2
Ensembl gene	ENSG00000263881
Ensembl biotype	miRNA
Entrez	100847033
RNAcentral	URS000075B423 — miRNA, 91 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581415

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581415 — 1 exons

Exon	Start	End
ENSE00002715180	110284853	110284943

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 83.89.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagus mucosa	UBERON:0002469	83.89	gold quality
duodenum	UBERON:0002114	82.41	gold quality
mucosa of transverse colon	UBERON:0004991	81.52	gold quality
lower esophagus mucosa	UBERON:0035834	80.89	gold quality
small intestine	UBERON:0002108	78.84	gold quality
ectocervix	UBERON:0012249	78.73	gold quality
small intestine Peyer’s patch	UBERON:0003454	78.34	gold quality
esophagus	UBERON:0001043	78.24	gold quality
transverse colon	UBERON:0001157	77.84	gold quality
rectum	UBERON:0001052	76.83	gold quality
intestine	UBERON:0000160	75.77	gold quality
colon	UBERON:0001155	74.14	gold quality
vermiform appendix	UBERON:0001154	73.18	gold quality
vagina	UBERON:0000996	72.57	gold quality
left uterine tube	UBERON:0001303	71.61	gold quality
muscle of leg	UBERON:0001383	71.61	gold quality
blood	UBERON:0000178	71.12	gold quality
islet of Langerhans	UBERON:0000006	70.98	gold quality
right coronary artery	UBERON:0001625	70.78	gold quality
tonsil	UBERON:0002372	70.53	gold quality
lung	UBERON:0002048	69.83	gold quality
gastrocnemius	UBERON:0001388	69.01	gold quality
upper lobe of left lung	UBERON:0008952	68.47	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.41	gold quality
smooth muscle tissue	UBERON:0001135	68.05	gold quality
calcaneal tendon	UBERON:0003701	67.79	gold quality
urinary bladder	UBERON:0001255	67.71	gold quality
gall bladder	UBERON:0002110	67.66	gold quality
omental fat pad	UBERON:0010414	67.40	gold quality
saliva-secreting gland	UBERON:0001044	67.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (1): MIR4436B1 (ENSG00000264979)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.