MIR4437

Summary

MIR4437 (microRNA 4437, HGNC:41715) is a microRNA gene on chromosome 2q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616213 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41715
Approved symbol	MIR4437
Name	microRNA 4437
Location	2q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4437
Ensembl gene	ENSG00000266705
Ensembl biotype	miRNA
Entrez	100616213
RNAcentral	URS000075BC91 — ncRNA, 60 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581331

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581331 — 1 exons

Exon	Start	End
ENSE00002697644	181305593	181305652

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 82.66.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.66	gold quality
bone marrow	UBERON:0002371	79.85	gold quality
monocyte	CL:0000576	74.07	gold quality
intestine	UBERON:0000160	70.65	gold quality
adult mammalian kidney	UBERON:0000082	70.58	gold quality
colon	UBERON:0001155	70.12	gold quality
skin of leg	UBERON:0001511	69.33	gold quality
small intestine	UBERON:0002108	68.92	gold quality
omental fat pad	UBERON:0010414	65.67	gold quality
right frontal lobe	UBERON:0002810	64.98	gold quality
lung	UBERON:0002048	64.80	gold quality
transverse colon	UBERON:0001157	64.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.49	gold quality
urinary bladder	UBERON:0001255	62.87	gold quality
spleen	UBERON:0002106	62.72	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.17	gold quality
minor salivary gland	UBERON:0001830	60.02	gold quality
liver	UBERON:0002107	57.03	gold quality
corpus callosum	UBERON:0002336	54.44	gold quality
stomach	UBERON:0000945	50.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• CXCR2 was a direct target of microRNA (miR)-4437, a negative regulator of CXCR2, which was downregulated in peripheral leucocytes from patients with ischemic stroke. (PMID:30096583)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.