MIR4438

Summary

MIR4438 (microRNA 4438, HGNC:41555) is a microRNA gene on chromosome 2q34.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616375 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41555
Approved symbol	MIR4438
Name	microRNA 4438
Location	2q34
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4438
Ensembl gene	ENSG00000265734
Ensembl biotype	miRNA
Entrez	100616375
RNAcentral	URS000075D31C — miRNA, 93 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585271

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585271 — 1 exons

Exon	Start	End
ENSE00002708709	213758067	213758159

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 67.26.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right adrenal gland	UBERON:0001233	67.26	gold quality
hypothalamus	UBERON:0001898	65.38	gold quality
right atrium auricular region	UBERON:0006631	64.57	gold quality
right frontal lobe	UBERON:0002810	64.42	gold quality
tibial artery	UBERON:0007610	62.16	gold quality
caudate nucleus	UBERON:0001873	62.07	gold quality
tibial nerve	UBERON:0001323	61.91	gold quality
pituitary gland	UBERON:0000007	61.07	gold quality
skin of abdomen	UBERON:0001416	59.75	gold quality
nucleus accumbens	UBERON:0001882	55.36	gold quality
left testis	UBERON:0004533	48.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.