MIR4439

Summary

MIR4439 (microRNA 4439, HGNC:41622) is a microRNA gene on chromosome 2q36.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616207 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41622
Approved symbol	MIR4439
Name	microRNA 4439
Location	2q36.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4439
Ensembl gene	ENSG00000263828
Ensembl biotype	miRNA
Entrez	100616207
RNAcentral	URS000075A963 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583746

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583746 — 1 exons

Exon	Start	End
ENSE00002722578	225010461	225010540

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 82.94.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.94	gold quality
corpus callosum	UBERON:0002336	82.06	gold quality
adrenal tissue	UBERON:0018303	79.28	gold quality
muscle of leg	UBERON:0001383	76.03	gold quality
heart	UBERON:0000948	75.39	gold quality
monocyte	CL:0000576	74.88	gold quality
gastrocnemius	UBERON:0001388	73.98	gold quality
lung	UBERON:0002048	73.03	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.79	gold quality
stomach	UBERON:0000945	71.40	gold quality
kidney	UBERON:0002113	70.29	gold quality
body of stomach	UBERON:0001161	70.24	gold quality
tibial artery	UBERON:0007610	69.64	gold quality
left adrenal gland	UBERON:0001234	69.57	gold quality
heart left ventricle	UBERON:0002084	69.06	gold quality
ascending aorta	UBERON:0001496	68.81	gold quality
granulocyte	CL:0000094	67.76	gold quality
putamen	UBERON:0001874	67.61	gold quality
thoracic aorta	UBERON:0001515	67.55	gold quality
anterior cingulate cortex	UBERON:0009835	67.34	gold quality
intestine	UBERON:0000160	67.02	gold quality
skin of leg	UBERON:0001511	66.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.10	gold quality
nucleus accumbens	UBERON:0001882	65.19	gold quality
right frontal lobe	UBERON:0002810	64.80	gold quality
hypothalamus	UBERON:0001898	64.72	gold quality
colon	UBERON:0001155	64.28	gold quality
zone of skin	UBERON:0000014	64.26	gold quality
left ovary	UBERON:0002119	63.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.