MIR4440

Summary

MIR4440 (microRNA 4440, HGNC:41740) is a microRNA gene on chromosome 2q37.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616397 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41740
Approved symbol	MIR4440
Name	microRNA 4440
Location	2q37.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4440
Ensembl gene	ENSG00000266109
Ensembl biotype	miRNA
Entrez	100616397
RNAcentral	URS000075C94C — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583986

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583986 — 1 exons

Exon	Start	End
ENSE00002704164	239068817	239068914

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 94.46.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	94.46	gold quality
muscle of leg	UBERON:0001383	93.69	gold quality
sural nerve	UBERON:0015488	92.43	gold quality
bone marrow	UBERON:0002371	91.03	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.12	gold quality
blood	UBERON:0000178	85.82	gold quality
colon	UBERON:0001155	85.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	85.39	gold quality
granulocyte	CL:0000094	85.31	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.93	gold quality
adrenal tissue	UBERON:0018303	84.91	gold quality
lower esophagus	UBERON:0013473	84.89	gold quality
lower esophagus mucosa	UBERON:0035834	84.66	gold quality
prefrontal cortex	UBERON:0000451	83.95	gold quality
skeletal muscle tissue	UBERON:0001134	83.56	gold quality
intestine	UBERON:0000160	83.28	gold quality
urinary bladder	UBERON:0001255	83.06	gold quality
endocervix	UBERON:0000458	83.01	gold quality
skin of abdomen	UBERON:0001416	82.72	gold quality
zone of skin	UBERON:0000014	82.34	gold quality
skin of leg	UBERON:0001511	82.22	gold quality
fundus of stomach	UBERON:0001160	82.11	gold quality
transverse colon	UBERON:0001157	82.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.98	gold quality
esophagus	UBERON:0001043	81.85	gold quality
monocyte	CL:0000576	81.49	gold quality
leukocyte	CL:0000738	81.38	gold quality
tibial nerve	UBERON:0001323	81.38	gold quality
right hemisphere of cerebellum	UBERON:0014890	81.25	gold quality
endometrium	UBERON:0001295	81.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.