MIR4441

Summary

MIR4441 (microRNA 4441, HGNC:41728) is a microRNA gene on chromosome 2q37.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616493 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41728
Approved symbol	MIR4441
Name	microRNA 4441
Location	2q37.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4441
Ensembl gene	ENSG00000264810
Ensembl biotype	miRNA
Entrez	100616493
RNAcentral	URS000075B6AD — miRNA, 100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582623

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582623 — 1 exons

Exon	Start	End
ENSE00002711024	239085827	239085926

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 95.64.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	95.64	gold quality
bone marrow	UBERON:0002371	93.96	gold quality
sural nerve	UBERON:0015488	91.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.08	gold quality
gastrocnemius	UBERON:0001388	87.89	gold quality
muscle of leg	UBERON:0001383	87.62	gold quality
muscle layer of sigmoid colon	UBERON:0035805	86.03	gold quality
adrenal tissue	UBERON:0018303	85.93	gold quality
blood	UBERON:0000178	85.91	gold quality
monocyte	CL:0000576	85.45	gold quality
calcaneal tendon	UBERON:0003701	85.01	gold quality
skeletal muscle tissue	UBERON:0001134	84.69	gold quality
duodenum	UBERON:0002114	84.07	gold quality
ectocervix	UBERON:0012249	83.71	gold quality
colon	UBERON:0001155	83.23	gold quality
vermiform appendix	UBERON:0001154	83.14	gold quality
skin of leg	UBERON:0001511	82.81	gold quality
skin of abdomen	UBERON:0001416	82.70	gold quality
zone of skin	UBERON:0000014	82.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	82.40	gold quality
lower esophagus	UBERON:0013473	82.29	gold quality
intestine	UBERON:0000160	82.04	gold quality
tibial nerve	UBERON:0001323	81.96	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.73	gold quality
body of uterus	UBERON:0009853	81.46	gold quality
smooth muscle tissue	UBERON:0001135	81.42	gold quality
right lung	UBERON:0002167	81.25	gold quality
stomach	UBERON:0000945	80.98	gold quality
left uterine tube	UBERON:0001303	80.55	gold quality
vagina	UBERON:0000996	80.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The Association between the Expression of MicroRNA-4270 and MicroRNA-4441 with some Metabolic Factors in Iranian Rheumatoid Arthritis Patients. (PMID:38477951)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.