MIR4442

Summary

MIR4442 (microRNA 4442, HGNC:41718) is a microRNA gene on chromosome 3p24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616477 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41718
Approved symbol	MIR4442
Name	microRNA 4442
Location	3p24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4442
Ensembl gene	ENSG00000283971
Ensembl biotype	miRNA
Entrez	100616477
RNAcentral	URS0000759FD5 — ncRNA, 67 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583412

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583412 — 1 exons

Exon	Start	End
ENSE00002697341	25664873	25664939

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 92.66.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 43.4911 / max 880.1026, expressed in 1816 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
41504	43.4911	1816

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	92.66	gold quality
adrenal tissue	UBERON:0018303	91.26	gold quality
endometrium	UBERON:0001295	90.40	gold quality
skeletal muscle tissue	UBERON:0001134	89.28	gold quality
monocyte	CL:0000576	88.72	gold quality
leukocyte	CL:0000738	87.82	gold quality
prefrontal cortex	UBERON:0000451	87.76	gold quality
calcaneal tendon	UBERON:0003701	87.76	gold quality
bone marrow	UBERON:0002371	86.62	gold quality
duodenum	UBERON:0002114	85.98	gold quality
sural nerve	UBERON:0015488	84.96	gold quality
placenta	UBERON:0001987	84.05	gold quality
mucosa of stomach	UBERON:0001199	83.20	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.99	gold quality
muscle of leg	UBERON:0001383	81.32	gold quality
lymph node	UBERON:0000029	80.86	gold quality
blood	UBERON:0000178	80.76	gold quality
popliteal artery	UBERON:0002250	80.49	gold quality
tibial artery	UBERON:0007610	80.47	gold quality
gastrocnemius	UBERON:0001388	80.46	gold quality
granulocyte	CL:0000094	79.31	gold quality
liver	UBERON:0002107	79.04	gold quality
left adrenal gland cortex	UBERON:0035825	78.89	gold quality
heart	UBERON:0000948	78.62	gold quality
body of uterus	UBERON:0009853	78.56	gold quality
left ovary	UBERON:0002119	78.53	gold quality
adrenal gland	UBERON:0002369	78.50	gold quality
ovary	UBERON:0000992	78.44	gold quality
right atrium auricular region	UBERON:0006631	78.20	gold quality
heart left ventricle	UBERON:0002084	78.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Roles of miR-4442 in Colorectal Cancer: Predicting Early Recurrence and Regulating Epithelial-Mesenchymal Transition. (PMID:37510319)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.