MIR4444-1

Summary

MIR4444-1 (microRNA 4444-1, HGNC:41710) is a microRNA gene on chromosome 2q31.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616394 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41710
Approved symbol	MIR4444-1
Name	microRNA 4444-1
Location	2q31.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4444, miR-4444-1
Ensembl gene	ENSG00000284252
Ensembl biotype	miRNA
Entrez	100616394
RNAcentral	URS000075B866 — ncRNA, 74 nt, 22 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581696

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581696 — 1 exons

Exon	Start	End
ENSE00001606825	177212726	177212799

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 76.64.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	76.64	gold quality
heart	UBERON:0000948	74.03	gold quality
blood	UBERON:0000178	72.23	gold quality
islet of Langerhans	UBERON:0000006	61.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (1): MIR4444-2 (ENSG00000266780)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.