MIR4445

Summary

MIR4445 (microRNA 4445, HGNC:41614) is a microRNA gene on chromosome 3q13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616129 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41614
Approved symbol	MIR4445
Name	microRNA 4445
Location	3q13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4445
Ensembl gene	ENSG00000265956
Ensembl biotype	miRNA
Entrez	100616129
RNAcentral	URS000075C5F2 — ncRNA, 70 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583183

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583183 — 1 exons

Exon	Start	End
ENSE00002727115	109602828	109602897

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 88.83.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.83	gold quality
thoracic aorta	UBERON:0001515	65.86	gold quality
ascending aorta	UBERON:0001496	65.49	gold quality
left testis	UBERON:0004533	42.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.