MIR4446

Summary

MIR4446 (microRNA 4446, HGNC:41700) is a microRNA gene on chromosome 3q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616476 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41700
Approved symbol	MIR4446
Name	microRNA 4446
Location	3q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4446
Ensembl gene	ENSG00000265253
Ensembl biotype	miRNA
Entrez	100616476
RNAcentral	URS000075A805 — miRNA, 67 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578505

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578505 — 1 exons

Exon	Start	End
ENSE00002692720	113594876	113594942

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 84.19.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	84.19	gold quality
blood	UBERON:0000178	82.09	gold quality
adrenal tissue	UBERON:0018303	76.73	gold quality
ascending aorta	UBERON:0001496	75.78	gold quality
corpus callosum	UBERON:0002336	73.34	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.16	gold quality
lymph node	UBERON:0000029	72.03	gold quality
stomach	UBERON:0000945	71.93	gold quality
islet of Langerhans	UBERON:0000006	71.86	gold quality
body of stomach	UBERON:0001161	71.02	gold quality
smooth muscle tissue	UBERON:0001135	70.83	gold quality
heart	UBERON:0000948	70.69	gold quality
omental fat pad	UBERON:0010414	69.73	gold quality
rectum	UBERON:0001052	69.37	gold quality
colon	UBERON:0001155	68.78	gold quality
body of pancreas	UBERON:0001150	67.97	gold quality
endometrium	UBERON:0001295	67.90	gold quality
transverse colon	UBERON:0001157	67.74	gold quality
skin of abdomen	UBERON:0001416	67.63	gold quality
intestine	UBERON:0000160	67.44	gold quality
fallopian tube	UBERON:0003889	67.35	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.24	gold quality
anterior cingulate cortex	UBERON:0009835	67.13	gold quality
minor salivary gland	UBERON:0001830	66.61	gold quality
esophagus mucosa	UBERON:0002469	66.25	gold quality
body of uterus	UBERON:0009853	65.28	gold quality
skin of leg	UBERON:0001511	65.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.08	gold quality
cerebellar hemisphere	UBERON:0002245	64.66	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.70

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Circulating Plasma MicroRNA in Patients With Active Acromegaly. (PMID:34550352)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.