MIR4447

Summary

MIR4447 (microRNA 4447, HGNC:41850) is a microRNA gene on chromosome 3q13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616485 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41850
Approved symbol	MIR4447
Name	microRNA 4447
Location	3q13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4447
Ensembl gene	ENSG00000265433
Ensembl biotype	miRNA
Entrez	100616485
RNAcentral	URS000075D28E — ncRNA, 91 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580126

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580126 — 1 exons

Exon	Start	End
ENSE00002714930	116850277	116850367

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 80.99.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.99	gold quality
heart	UBERON:0000948	80.60	gold quality
monocyte	CL:0000576	79.59	gold quality
sural nerve	UBERON:0015488	78.57	gold quality
intestine	UBERON:0000160	76.97	gold quality
endometrium	UBERON:0001295	74.99	gold quality
kidney	UBERON:0002113	73.58	gold quality
corpus callosum	UBERON:0002336	73.05	gold quality
lung	UBERON:0002048	72.50	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.18	gold quality
tibial nerve	UBERON:0001323	71.05	gold quality
vagina	UBERON:0000996	69.50	gold quality
stomach	UBERON:0000945	69.10	gold quality
Ammon’s horn	UBERON:0001954	67.20	gold quality
putamen	UBERON:0001874	65.77	gold quality
upper lobe of left lung	UBERON:0008952	65.42	gold quality
nucleus accumbens	UBERON:0001882	65.36	gold quality
brain	UBERON:0000955	64.95	gold quality
transverse colon	UBERON:0001157	64.62	gold quality
hypothalamus	UBERON:0001898	63.63	gold quality
spleen	UBERON:0002106	63.15	gold quality
caudate nucleus	UBERON:0001873	62.92	gold quality
amygdala	UBERON:0001876	62.65	gold quality
left ovary	UBERON:0002119	62.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.12	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.68	gold quality
anterior cingulate cortex	UBERON:0009835	61.48	gold quality
tibial artery	UBERON:0007610	60.93	gold quality
left adrenal gland	UBERON:0001234	60.35	gold quality
right frontal lobe	UBERON:0002810	59.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.54

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.