MIR4448

Summary

MIR4448 (microRNA 4448, HGNC:41604) is a microRNA gene on chromosome 3q27.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616127 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41604
Approved symbol	MIR4448
Name	microRNA 4448
Location	3q27.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4448
Ensembl gene	ENSG00000263932
Ensembl biotype	miRNA
Entrez	100616127
RNAcentral	URS000075C68B — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584360

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584360 — 1 exons

Exon	Start	End
ENSE00002729345	183886800	183886885

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 78.62.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
myometrium	UBERON:0001296	78.62	gold quality
right lobe of liver	UBERON:0001114	70.90	gold quality
blood	UBERON:0000178	70.76	gold quality
adrenal gland	UBERON:0002369	69.77	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.73	gold quality
endometrium	UBERON:0001295	69.28	gold quality
adipose tissue	UBERON:0001013	68.13	gold quality
lung	UBERON:0002048	67.84	gold quality
transverse colon	UBERON:0001157	67.80	gold quality
body of pancreas	UBERON:0001150	67.66	gold quality
body of uterus	UBERON:0009853	67.35	gold quality
hypothalamus	UBERON:0001898	67.34	gold quality
heart left ventricle	UBERON:0002084	67.22	gold quality
liver	UBERON:0002107	66.76	gold quality
leukocyte	CL:0000738	66.67	gold quality
esophagus mucosa	UBERON:0002469	66.04	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.51	gold quality
skin of abdomen	UBERON:0001416	65.17	gold quality
vagina	UBERON:0000996	65.07	gold quality
omental fat pad	UBERON:0010414	64.56	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.48	gold quality
anterior cingulate cortex	UBERON:0009835	63.37	gold quality
tibial nerve	UBERON:0001323	62.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.25	gold quality
caudate nucleus	UBERON:0001873	61.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.65	gold quality
cerebellar hemisphere	UBERON:0002245	61.37	gold quality
substantia nigra	UBERON:0002038	60.94	gold quality
left lobe of thyroid gland	UBERON:0001120	60.07	gold quality
adult mammalian kidney	UBERON:0000082	58.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.