MIR4449

Summary

MIR4449 (microRNA 4449, HGNC:41864) is a microRNA gene on chromosome 4q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616436 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41864
Approved symbol	MIR4449
Name	microRNA 4449
Location	4q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4449
Ensembl gene	ENSG00000264585
Ensembl biotype	miRNA
OMIM	614627
Entrez	100616436
RNAcentral	URS000075B0DE — miRNA, 66 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578365

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578365 — 1 exons

Exon	Start	End
ENSE00002694634	52712682	52712747

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 95.66.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.66	gold quality
liver	UBERON:0002107	89.10	gold quality
stomach	UBERON:0000945	75.67	gold quality
body of stomach	UBERON:0001161	70.57	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.33	gold quality
skin of leg	UBERON:0001511	67.92	gold quality
blood	UBERON:0000178	64.69	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.70	gold quality
right frontal lobe	UBERON:0002810	62.19	gold quality
Ammon’s horn	UBERON:0001954	60.72	gold quality
esophagus mucosa	UBERON:0002469	60.64	gold quality
brain	UBERON:0000955	59.27	gold quality
prostate gland	UBERON:0002367	59.10	gold quality
hypothalamus	UBERON:0001898	59.04	gold quality
left ovary	UBERON:0002119	57.45	gold quality
cerebellar hemisphere	UBERON:0002245	57.23	gold quality
right hemisphere of cerebellum	UBERON:0014890	52.88	gold quality
adult mammalian kidney	UBERON:0000082	49.48	gold quality
transverse colon	UBERON:0001157	42.98	gold quality
pituitary gland	UBERON:0000007	38.00	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• expression levels of serum miR-4449 in MM patients were significantly higher than in healthy control (PMID:27155004)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.