MIR4450

Summary

MIR4450 (microRNA 4450, HGNC:41725) is a microRNA gene on chromosome 4q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616299 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41725
Approved symbol	MIR4450
Name	microRNA 4450
Location	4q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4450
Ensembl gene	ENSG00000263445
Ensembl biotype	miRNA
Entrez	100616299
RNAcentral	URS000075B4EA — ncRNA, 65 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583589

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583589 — 1 exons

Exon	Start	End
ENSE00002698843	76573568	76573632

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 78.09.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	78.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.91	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.64	gold quality
heart left ventricle	UBERON:0002084	74.40	gold quality
gall bladder	UBERON:0002110	73.89	gold quality
monocyte	CL:0000576	73.42	gold quality
stomach	UBERON:0000945	73.27	gold quality
heart	UBERON:0000948	70.92	gold quality
right lobe of liver	UBERON:0001114	70.91	gold quality
thoracic mammary gland	UBERON:0005200	70.72	gold quality
right lobe of thyroid gland	UBERON:0001119	69.98	gold quality
right atrium auricular region	UBERON:0006631	69.43	gold quality
body of pancreas	UBERON:0001150	69.35	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.16	gold quality
tibial artery	UBERON:0007610	68.49	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.44	gold quality
lower esophagus	UBERON:0013473	68.28	gold quality
saliva-secreting gland	UBERON:0001044	68.25	gold quality
ascending aorta	UBERON:0001496	68.12	gold quality
adult mammalian kidney	UBERON:0000082	67.86	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.86	gold quality
endometrium	UBERON:0001295	67.41	gold quality
minor salivary gland	UBERON:0001830	67.30	gold quality
prostate gland	UBERON:0002367	67.30	gold quality
skin of abdomen	UBERON:0001416	66.85	gold quality
body of stomach	UBERON:0001161	66.80	gold quality
esophagus mucosa	UBERON:0002469	66.62	gold quality
left lobe of thyroid gland	UBERON:0001120	66.58	gold quality
anterior cingulate cortex	UBERON:0009835	66.48	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.