MIR4451

Summary

MIR4451 (microRNA 4451, HGNC:41858) is a microRNA gene on chromosome 4q21.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616349 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41858
Approved symbol	MIR4451
Name	microRNA 4451
Location	4q21.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4451
Ensembl gene	ENSG00000266421
Ensembl biotype	miRNA
Entrez	100616349
RNAcentral	URS000075B8AC — miRNA, 66 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580577

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580577 — 1 exons

Exon	Start	End
ENSE00002726538	85722468	85722533

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 84.52.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.52	gold quality
calcaneal tendon	UBERON:0003701	81.22	gold quality
bone marrow	UBERON:0002371	80.33	gold quality
blood	UBERON:0000178	79.77	gold quality
stomach	UBERON:0000945	78.61	gold quality
monocyte	CL:0000576	77.88	gold quality
kidney	UBERON:0002113	76.32	gold quality
ectocervix	UBERON:0012249	75.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.75	gold quality
placenta	UBERON:0001987	74.03	gold quality
adrenal gland	UBERON:0002369	73.91	gold quality
liver	UBERON:0002107	73.69	gold quality
heart	UBERON:0000948	73.40	gold quality
right atrium auricular region	UBERON:0006631	71.90	gold quality
urinary bladder	UBERON:0001255	71.86	gold quality
heart left ventricle	UBERON:0002084	71.55	gold quality
gastrocnemius	UBERON:0001388	71.51	gold quality
body of stomach	UBERON:0001161	71.47	gold quality
tonsil	UBERON:0002372	71.47	gold quality
smooth muscle tissue	UBERON:0001135	71.13	gold quality
lung	UBERON:0002048	70.89	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.85	gold quality
adenohypophysis	UBERON:0002196	70.33	gold quality
intestine	UBERON:0000160	69.72	gold quality
colon	UBERON:0001155	69.66	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.53	gold quality
body of pancreas	UBERON:0001150	69.50	gold quality
tibial artery	UBERON:0007610	69.39	gold quality
Ammon’s horn	UBERON:0001954	68.78	gold quality
substantia nigra	UBERON:0002038	68.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A 3-miRNA signature predicts survival of patients with hypopharyngeal squamous cell carcinoma after post-operative radiotherapy. (PMID:31578816)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.