MIR4452

Summary

MIR4452 (microRNA 4452, HGNC:41539) is a microRNA gene on chromosome 4q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616463 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41539
Approved symbol	MIR4452
Name	microRNA 4452
Location	4q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4452
Ensembl gene	ENSG00000266515
Ensembl biotype	miRNA
Entrez	100616463
RNAcentral	URS000075B8FF — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583004

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583004 — 1 exons

Exon	Start	End
ENSE00002711232	86542482	86542552

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 74.78.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	74.78	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.65	gold quality
body of pancreas	UBERON:0001150	68.94	gold quality
pituitary gland	UBERON:0000007	66.07	gold quality
right lobe of thyroid gland	UBERON:0001119	65.62	gold quality
esophagus mucosa	UBERON:0002469	64.89	gold quality
hypothalamus	UBERON:0001898	64.68	gold quality
adipose tissue	UBERON:0001013	64.13	gold quality
right ovary	UBERON:0002118	64.01	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.86	gold quality
omental fat pad	UBERON:0010414	62.77	gold quality
left ovary	UBERON:0002119	62.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.31	gold quality
left lobe of thyroid gland	UBERON:0001120	61.68	gold quality
thyroid gland	UBERON:0002046	61.24	gold quality
lung	UBERON:0002048	60.30	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.89	gold quality
upper lobe of left lung	UBERON:0008952	59.70	gold quality
caudate nucleus	UBERON:0001873	58.72	gold quality
tibial nerve	UBERON:0001323	58.50	gold quality
metanephros cortex	UBERON:0010533	57.44	gold quality
vagina	UBERON:0000996	53.89	gold quality
right testis	UBERON:0004534	53.07	gold quality
left testis	UBERON:0004533	44.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.