MIR4453

Summary

MIR4453 (microRNA 4453, HGNC:41892) is a microRNA gene on chromosome 4q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616193 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41892
Approved symbol	MIR4453
Name	microRNA 4453
Location	4q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4453
Ensembl gene	ENSG00000283792
Ensembl biotype	miRNA
Entrez	100616193
RNAcentral	URS000075D7DA — ncRNA, 89 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584019

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584019 — 1 exons

Exon	Start	End
ENSE00002702340	152536428	152536516

Expression profiles

Bgee: expression breadth broad, 35 present calls, max score 72.75.

FANTOM5 (CAGE): breadth broad, TPM avg 1.5156 / max 32.3279, expressed in 752 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
50028	1.5156	752

Top tissues by expression

35 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	72.75	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.48	gold quality
colon	UBERON:0001155	71.69	gold quality
gastrocnemius	UBERON:0001388	69.68	gold quality
spleen	UBERON:0002106	68.87	gold quality
blood	UBERON:0000178	66.50	gold quality
heart left ventricle	UBERON:0002084	66.45	gold quality
caudate nucleus	UBERON:0001873	66.23	gold quality
islet of Langerhans	UBERON:0000006	65.95	gold quality
small intestine	UBERON:0002108	65.59	gold quality
left adrenal gland cortex	UBERON:0035825	64.77	gold quality
lymph node	UBERON:0000029	64.64	gold quality
skin of abdomen	UBERON:0001416	63.45	gold quality
hypothalamus	UBERON:0001898	62.99	gold quality
putamen	UBERON:0001874	60.75	gold quality
ascending aorta	UBERON:0001496	59.86	gold quality
esophagus mucosa	UBERON:0002469	59.70	gold quality
small intestine Peyer’s patch	UBERON:0003454	58.04	gold quality
anterior cingulate cortex	UBERON:0009835	57.22	gold quality
zone of skin	UBERON:0000014	56.99	gold quality
placenta	UBERON:0001987	55.48	gold quality
body of stomach	UBERON:0001161	54.92	gold quality
brain	UBERON:0000955	54.52	gold quality
omental fat pad	UBERON:0010414	54.08	gold quality
subcutaneous adipose tissue	UBERON:0002190	53.21	gold quality
nucleus accumbens	UBERON:0001882	52.94	gold quality
right adrenal gland	UBERON:0001233	52.62	gold quality
tibial artery	UBERON:0007610	51.92	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	50.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	47.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.