MIR4453HG

Summary

MIR4453HG (MIR4453 host gene, HGNC:25288) is a long non-coding RNA gene on chromosome 4q31.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25288
Approved symbol	MIR4453HG
Name	MIR4453 host gene
Location	4q31.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	DKFZP434I0714
Ensembl gene	ENSG00000268471
Ensembl biotype	lncRNA
Entrez	54553
RNAcentral	URS000075C05C — lncRNA, 3020 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000604157

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000604157 — 1 exons

Exon	Start	End
ENSE00004071192	152536260	152539263

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 85.09.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9346 / max 21.3684, expressed in 553 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
50027	0.9346	553

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	85.09	gold quality
epithelial cell of pancreas	CL:0000083	83.23	silver quality
esophagus squamous epithelium	UBERON:0006920	80.30	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.56	gold quality
tibia	UBERON:0000979	78.84	silver quality
ganglionic eminence	UBERON:0004023	77.91	gold quality
ileal mucosa	UBERON:0000331	77.83	gold quality
pigmented layer of retina	UBERON:0001782	76.94	gold quality
ventricular zone	UBERON:0003053	76.22	gold quality
pituitary gland	UBERON:0000007	76.04	gold quality
adenohypophysis	UBERON:0002196	75.82	gold quality
islet of Langerhans	UBERON:0000006	74.21	gold quality
right uterine tube	UBERON:0001302	74.16	gold quality
cerebellar hemisphere	UBERON:0002245	73.71	gold quality
cerebellar cortex	UBERON:0002129	73.58	gold quality
right hemisphere of cerebellum	UBERON:0014890	73.54	gold quality
lower esophagus mucosa	UBERON:0035834	73.35	gold quality
left ovary	UBERON:0002119	73.07	gold quality
tibialis anterior	UBERON:0001385	73.01	silver quality
rectum	UBERON:0001052	72.97	gold quality
cerebellum	UBERON:0002037	72.76	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.62	gold quality
corpus epididymis	UBERON:0004359	72.57	silver quality
vermiform appendix	UBERON:0001154	72.33	gold quality
left lobe of thyroid gland	UBERON:0001120	71.94	gold quality
metanephros cortex	UBERON:0010533	71.87	gold quality
right lobe of thyroid gland	UBERON:0001119	71.73	gold quality
thyroid gland	UBERON:0002046	71.73	gold quality
body of uterus	UBERON:0009853	71.69	gold quality
right ovary	UBERON:0002118	71.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.