MIR4454

Summary

MIR4454 (microRNA 4454, HGNC:41553) is a microRNA gene on chromosome 4q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616234 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41553
Approved symbol	MIR4454
Name	microRNA 4454
Location	4q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4454
Ensembl gene	ENSG00000283468
Ensembl biotype	miRNA
Entrez	100616234
RNAcentral	URS000075D025 — miRNA, 55 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000638111

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000638111 — 1 exons

Exon	Start	End
ENSE00003801148	163093574	163093628

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 87.76.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.76	gold quality
sural nerve	UBERON:0015488	82.25	gold quality
prefrontal cortex	UBERON:0000451	76.49	gold quality
monocyte	CL:0000576	75.38	gold quality
blood	UBERON:0000178	74.78	gold quality
gastrocnemius	UBERON:0001388	74.66	gold quality
heart left ventricle	UBERON:0002084	72.24	gold quality
spleen	UBERON:0002106	70.00	gold quality
body of uterus	UBERON:0009853	69.09	gold quality
brain	UBERON:0000955	68.71	gold quality
descending thoracic aorta	UBERON:0002345	67.85	gold quality
substantia nigra	UBERON:0002038	67.74	gold quality
body of pancreas	UBERON:0001150	67.60	gold quality
tibial nerve	UBERON:0001323	67.44	gold quality
left adrenal gland	UBERON:0001234	67.06	gold quality
body of stomach	UBERON:0001161	67.04	gold quality
tibial artery	UBERON:0007610	66.33	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.29	gold quality
esophagus mucosa	UBERON:0002469	65.96	gold quality
upper lobe of left lung	UBERON:0008952	65.76	gold quality
vagina	UBERON:0000996	65.75	gold quality
thyroid gland	UBERON:0002046	65.67	gold quality
thoracic mammary gland	UBERON:0005200	65.33	gold quality
skin of leg	UBERON:0001511	65.23	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.64	gold quality
pituitary gland	UBERON:0000007	63.18	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.12	gold quality
left lobe of thyroid gland	UBERON:0001120	62.65	gold quality
fallopian tube	UBERON:0003889	62.44	gold quality
prostate gland	UBERON:0002367	62.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• The top 3 (abundant) miRNAs detected were as follows: miR-125b-5p, miR-4454, and miR-451a. qRT-PCR revealed higher abundance of miR-451a than others. Only miR-4454 and miR-451a abundance tended to increase with increasing storage time. The function of exosomes (RBC-derived) might be implemented partly by the predominantly enriched miR-451a. (PMID:31312654)
• Data found that miR-4454 is not synthesized from its annotated genomic locus, which is a primer-binding site for an endogenous retrovirus, but rather by Dicer cleavage of mature tRNAHis. Sequence analysis revealed that miR-4454 is identical to the 3’ end of tRNAHis. (PMID:31329584)
• Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation. (PMID:32350057)
• miR-4454 up-regulated by HPV16 E6/E7 promotes invasion and migration by targeting ABHD2/NUDT21 in cervical cancer. (PMID:32816024)
• Influence of Obesity in the miRNome: miR-4454, a Key Regulator of Insulin Response Via Splicing Modulation in Prostate. (PMID:32841353)
• miR-4454 Promotes Hepatic Carcinoma Progression by Targeting Vps4A and Rab27A. (PMID:34777698)
• Human Endogenous Retrovirus-H-Derived miR-4454 Inhibits the Expression of DNAJB4 and SASH1 in Non-Muscle-Invasive Bladder Cancer. (PMID:37510314)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.