MIR4455

Summary

MIR4455 (microRNA 4455, HGNC:41536) is a microRNA gene on chromosome 4q35.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616111 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41536
Approved symbol	MIR4455
Name	microRNA 4455
Location	4q35.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4455
Ensembl gene	ENSG00000263458
Ensembl biotype	miRNA
Entrez	100616111
RNAcentral	URS000075DAAD — ncRNA, 58 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580836

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580836 — 1 exons

Exon	Start	End
ENSE00002696229	184938383	184938440

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 76.55.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.55	gold quality
lung	UBERON:0002048	75.01	gold quality
liver	UBERON:0002107	73.43	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.91	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.83	gold quality
left lobe of thyroid gland	UBERON:0001120	68.42	gold quality
caudate nucleus	UBERON:0001873	67.40	gold quality
skin of abdomen	UBERON:0001416	64.34	gold quality
spleen	UBERON:0002106	60.82	gold quality
omental fat pad	UBERON:0010414	60.53	gold quality
right testis	UBERON:0004534	48.39	gold quality
left testis	UBERON:0004533	47.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.