MIR4456

Summary

MIR4456 (microRNA 4456, HGNC:41606) is a microRNA gene on chromosome 5p15.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616381 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41606
Approved symbol	MIR4456
Name	microRNA 4456
Location	5p15.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4456
Ensembl gene	ENSG00000264233
Ensembl biotype	miRNA
Entrez	100616381
RNAcentral	URS000075D1E8 — miRNA, 43 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582112

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582112 — 1 exons

Exon	Start	End
ENSE00002696381	535840	535882

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 83.57.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of stomach	UBERON:0001161	83.57	gold quality
gastrocnemius	UBERON:0001388	82.64	gold quality
stomach	UBERON:0000945	79.93	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	79.08	gold quality
blood	UBERON:0000178	75.67	gold quality
adult mammalian kidney	UBERON:0000082	75.50	gold quality
kidney	UBERON:0002113	72.87	gold quality
endocervix	UBERON:0000458	70.99	gold quality
tibial nerve	UBERON:0001323	67.78	gold quality
skin of leg	UBERON:0001511	65.31	gold quality
metanephros cortex	UBERON:0010533	64.56	gold quality
transverse colon	UBERON:0001157	63.61	gold quality
right testis	UBERON:0004534	51.30	gold quality
left testis	UBERON:0004533	50.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Hypermethylation-associated downregulation of microRNA-4456 in hypersexual disorder with putative influence on oxytocin signalling: A DNA methylation analysis of miRNA genes. (PMID:31542994)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.