MIR4457

Summary

MIR4457 (microRNA 4457, HGNC:41554) is a microRNA gene on chromosome 5p15.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616235 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41554
Approved symbol	MIR4457
Name	microRNA 4457
Location	5p15.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4457
Ensembl gene	ENSG00000263670
Ensembl biotype	miRNA
Entrez	100616235
RNAcentral	URS000075B35D — miRNA, 68 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580663

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580663 — 1 exons

Exon	Start	End
ENSE00002734746	1309310	1309377

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 81.15.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	81.15	gold quality
monocyte	CL:0000576	74.64	gold quality
fundus of stomach	UBERON:0001160	74.27	gold quality
islet of Langerhans	UBERON:0000006	73.27	gold quality
skin of abdomen	UBERON:0001416	71.07	gold quality
minor salivary gland	UBERON:0001830	69.14	gold quality
transverse colon	UBERON:0001157	67.44	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.91	gold quality
lung	UBERON:0002048	62.19	gold quality
body of stomach	UBERON:0001161	61.47	gold quality
skin of leg	UBERON:0001511	60.80	gold quality
spleen	UBERON:0002106	60.13	gold quality
corpus callosum	UBERON:0002336	59.04	gold quality
thoracic mammary gland	UBERON:0005200	54.92	gold quality
right frontal lobe	UBERON:0002810	47.65	gold quality
left testis	UBERON:0004533	44.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.