MIR4458

Summary

MIR4458 (microRNA 4458, HGNC:41674) is a microRNA gene on chromosome 5p15.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616142 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41674
Approved symbol	MIR4458
Name	microRNA 4458
Location	5p15.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4458
Ensembl gene	ENSG00000284000
Ensembl biotype	miRNA
Entrez	100616142
RNAcentral	URS000075DE80 — ncRNA, 75 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578872

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578872 — 1 exons

Exon	Start	End
ENSE00002722677	8460925	8460999

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 80.60.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	80.60	gold quality
muscle of leg	UBERON:0001383	80.51	gold quality
esophagus mucosa	UBERON:0002469	65.07	gold quality
heart left ventricle	UBERON:0002084	56.44	gold quality
body of stomach	UBERON:0001161	56.34	gold quality
skin of leg	UBERON:0001511	53.63	gold quality
prostate gland	UBERON:0002367	51.95	gold quality
omental fat pad	UBERON:0010414	50.51	gold quality
subcutaneous adipose tissue	UBERON:0002190	48.74	gold quality
small intestine Peyer’s patch	UBERON:0003454	47.37	gold quality
skin of abdomen	UBERON:0001416	46.03	silver quality
testis	UBERON:0000473	45.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 15)

• The role of miR-4458 in HCC, and miR-4458 inhibited HCC cell viability via targeting IKBKE. (PMID:25833000)
• 3 novel miRNAs, MIR4458, MIR4667-5p, and MIR4668-5p, regulate autophagy-mediated elimination of B. pseudomallei by targeting ATG10 (PMID:26151773)
• In conclusion, our findings suggested that miR-4458 inhibited the progression of colon cancer cells by inhibition of glycolysis and lactate production via directly targeting HK2 mRNA. (PMID:26607110)
• miR-4458 regulates cell proliferation and apoptosis through targeting SOCS1 in triple-negative breast cancer. (PMID:30873664)
• MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4; results suggest that the miR-4458-CPSF4-COX-2-hTERT axis might serve as a potential target for the treatment of breast cancer patients (PMID:30970220)
• the results of rescue experiments suggested that the oncogenic role of KCNQ1OT1 was performed through sponging miR-4458 and upregulating CCND2 during osteosarcoma development, providing a novel perspective of intervention in osteosarcoma management. (PMID:31392505)
• miR-4458 had a high correlation score in TNBC tissues, and HEIH directly binds to miR-4458, and negatively regulates miR-4458 expression in TNBC cells. (PMID:31456112)
• Long non-coding RNA CDKN2B-AS1 promotes osteosarcoma by increasing the expression of MAP3K3 via sponging miR-4458. (PMID:31950433)
• MiR-4458/human antigen R (HuR) modulates PBX3 mRNA stability in melanoma tumorigenesis. (PMID:32157373)
• miR-4458 inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing the TGF-beta signaling pathway via targeting TGFBR1. (PMID:32324847)
• Circular RNA circ_0000337 contributes to osteosarcoma via the miR-4458/BACH1 pathway. (PMID:32390598)
• LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway. (PMID:33658535)
• MicroRNA-4458 Regulates PD-L1 Expression to Enhance Anti-tumor Immunity in NSCLC via Targeting STAT3. (PMID:34386930)
• LINC00963/miR-4458 regulates the effect of oxaliplatin in gastric cancer by mediating autophagic flux through targeting of ATG16L1. (PMID:34697403)
• Circular RNA circHMCU promotes breast tumorigenesis through miR-4458/PGK1 regulatory cascade. (PMID:36949536)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.