MIR4458HG

Summary

MIR4458HG (MIR4458 host gene, HGNC:49008) is a long non-coding RNA gene on chromosome 5p15.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49008
Approved symbol	MIR4458HG
Name	MIR4458 host gene
Location	5p15.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000247516
Ensembl biotype	lncRNA
Entrez	100505738
RNAcentral	URS000075E955 — lncRNA, 3260 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000502001, ENST00000605918, ENST00000606459, ENST00000652260, ENST00000660398, ENST00000664641, ENST00000667556, ENST00000669529, ENST00000669539, ENST00000669566, ENST00000669668, ENST00000670196, ENST00000721170, ENST00000721171

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000502001 — 2 exons

Exon	Start	End
ENSE00001975338	8457493	8457766
ENSE00001991046	8459933	8460663

Expression profiles

Bgee: expression breadth ubiquitous, 182 present calls, max score 88.36.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.4374 / max 321.8202, expressed in 1517 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
55677	17.4374	1517

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	88.36	gold quality
muscle of leg	UBERON:0001383	86.47	gold quality
calcaneal tendon	UBERON:0003701	86.23	gold quality
gastrocnemius	UBERON:0001388	86.17	gold quality
apex of heart	UBERON:0002098	84.94	gold quality
mucosa of transverse colon	UBERON:0004991	83.39	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.33	gold quality
heart left ventricle	UBERON:0002084	83.26	gold quality
right atrium auricular region	UBERON:0006631	82.70	gold quality
cardiac ventricle	UBERON:0002082	82.62	gold quality
islet of Langerhans	UBERON:0000006	81.47	gold quality
popliteal artery	UBERON:0002250	81.24	gold quality
tibial artery	UBERON:0007610	81.23	gold quality
cardiac atrium	UBERON:0002081	81.13	gold quality
heart	UBERON:0000948	80.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	80.62	gold quality
adenohypophysis	UBERON:0002196	80.61	gold quality
lower esophagus	UBERON:0013473	80.58	gold quality
left lobe of thyroid gland	UBERON:0001120	79.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	79.92	gold quality
right coronary artery	UBERON:0001625	79.45	gold quality
aorta	UBERON:0000947	79.33	gold quality
metanephros cortex	UBERON:0010533	79.26	gold quality
body of stomach	UBERON:0001161	78.99	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.89	gold quality
adult mammalian kidney	UBERON:0000082	78.82	gold quality
left coronary artery	UBERON:0001626	78.67	gold quality
muscle layer of sigmoid colon	UBERON:0035805	78.54	gold quality
thyroid gland	UBERON:0002046	78.10	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• lncRNA miR4458HG modulates hepatocellular carcinoma progression by activating m6A-dependent glycolysis and promoting the polarization of tumor-associated macrophages. (PMID:36933158)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.