MIR4460

Summary

MIR4460 (microRNA 4460, HGNC:41795) is a microRNA gene on chromosome 5q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616325 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41795
Approved symbol	MIR4460
Name	microRNA 4460
Location	5q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4460
Ensembl gene	ENSG00000265691
Ensembl biotype	miRNA
Entrez	100616325
RNAcentral	URS000075CF7B — ncRNA, 86 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577862

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577862 — 1 exons

Exon	Start	End
ENSE00002696091	129397062	129397147

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 78.24.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	78.24	gold quality
blood	UBERON:0000178	75.64	gold quality
kidney	UBERON:0002113	75.03	gold quality
stomach	UBERON:0000945	74.34	gold quality
gastrocnemius	UBERON:0001388	73.65	gold quality
islet of Langerhans	UBERON:0000006	72.15	gold quality
lung	UBERON:0002048	70.63	gold quality
heart left ventricle	UBERON:0002084	69.73	gold quality
intestine	UBERON:0000160	68.91	gold quality
body of pancreas	UBERON:0001150	68.35	gold quality
esophagus mucosa	UBERON:0002469	67.97	gold quality
urinary bladder	UBERON:0001255	67.43	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.81	gold quality
transverse colon	UBERON:0001157	66.00	gold quality
skin of leg	UBERON:0001511	65.93	gold quality
adipose tissue	UBERON:0001013	65.67	gold quality
right atrium auricular region	UBERON:0006631	65.41	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.29	gold quality
corpus callosum	UBERON:0002336	64.94	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.89	gold quality
body of uterus	UBERON:0009853	64.73	gold quality
minor salivary gland	UBERON:0001830	63.90	gold quality
left ovary	UBERON:0002119	63.40	gold quality
body of stomach	UBERON:0001161	63.33	gold quality
right ovary	UBERON:0002118	62.79	gold quality
myometrium	UBERON:0001296	62.77	gold quality
omental fat pad	UBERON:0010414	62.20	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.63	gold quality
skin of abdomen	UBERON:0001416	61.54	gold quality
left lobe of thyroid gland	UBERON:0001120	60.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.