MIR4462

Summary

MIR4462 (microRNA 4462, HGNC:41549) is a microRNA gene on chromosome 6p21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616413 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41549
Approved symbol	MIR4462
Name	microRNA 4462
Location	6p21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4462
Ensembl gene	ENSG00000263926
Ensembl biotype	miRNA
Entrez	100616413
RNAcentral	URS000075EEC1 — ncRNA, 58 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579627

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579627 — 1 exons

Exon	Start	End
ENSE00002705682	37555365	37555422

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 84.84.

Top tissues by expression

43 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	84.84	gold quality
blood	UBERON:0000178	76.08	gold quality
lymph node	UBERON:0000029	74.78	gold quality
tonsil	UBERON:0002372	71.42	gold quality
caudate nucleus	UBERON:0001873	70.90	gold quality
lung	UBERON:0002048	69.81	gold quality
body of stomach	UBERON:0001161	68.84	gold quality
liver	UBERON:0002107	68.77	gold quality
upper lobe of left lung	UBERON:0008952	68.72	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.28	gold quality
anterior cingulate cortex	UBERON:0009835	68.08	gold quality
colon	UBERON:0001155	66.59	gold quality
thyroid gland	UBERON:0002046	66.25	gold quality
esophagus	UBERON:0001043	65.99	gold quality
transverse colon	UBERON:0001157	65.94	gold quality
nucleus accumbens	UBERON:0001882	65.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.52	gold quality
omental fat pad	UBERON:0010414	65.40	gold quality
thoracic aorta	UBERON:0001515	65.35	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.24	gold quality
esophagus mucosa	UBERON:0002469	64.95	gold quality
skin of leg	UBERON:0001511	64.94	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.83	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.82	gold quality
minor salivary gland	UBERON:0001830	64.68	gold quality
left lobe of thyroid gland	UBERON:0001120	64.48	gold quality
spleen	UBERON:0002106	64.28	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.13	gold quality
vagina	UBERON:0000996	63.96	gold quality
skin of abdomen	UBERON:0001416	63.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.