MIR4463

Summary

MIR4463 (microRNA 4463, HGNC:41665) is a microRNA gene on chromosome 6q14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616389 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41665
Approved symbol	MIR4463
Name	microRNA 4463
Location	6q14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4463
Ensembl gene	ENSG00000263533
Ensembl biotype	miRNA
Entrez	100616389
RNAcentral	URS000075ABF8 — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580609

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580609 — 1 exons

Exon	Start	End
ENSE00002699365	75428407	75428473

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 88.70.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	88.70	gold quality
calcaneal tendon	UBERON:0003701	87.84	gold quality
lung	UBERON:0002048	79.48	gold quality
muscle of leg	UBERON:0001383	76.90	gold quality
adrenal tissue	UBERON:0018303	76.61	gold quality
blood	UBERON:0000178	74.52	gold quality
gastrocnemius	UBERON:0001388	74.31	gold quality
heart	UBERON:0000948	71.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.01	gold quality
tibial artery	UBERON:0007610	69.90	gold quality
heart left ventricle	UBERON:0002084	69.81	gold quality
thoracic aorta	UBERON:0001515	69.08	gold quality
intestine	UBERON:0000160	68.01	gold quality
fundus of stomach	UBERON:0001160	67.93	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.69	gold quality
ascending aorta	UBERON:0001496	67.37	gold quality
colon	UBERON:0001155	66.98	gold quality
right atrium auricular region	UBERON:0006631	66.88	gold quality
stomach	UBERON:0000945	66.81	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.82	gold quality
transverse colon	UBERON:0001157	65.64	gold quality
liver	UBERON:0002107	64.88	gold quality
omental fat pad	UBERON:0010414	64.56	gold quality
thyroid gland	UBERON:0002046	64.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.49	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.00	gold quality
tibial nerve	UBERON:0001323	61.52	gold quality
body of uterus	UBERON:0009853	59.03	gold quality
testis	UBERON:0000473	44.88	gold quality
left testis	UBERON:0004533	44.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• The level of miR-4463 was significantly increased in Arteriosclerosis Obliterans. (PMID:26370316)
• the upregulation of miR4463 may enhance hydrogen peroxideinduced oxidative stress and promote apoptosis in human umbilical vein endothelial cells in vitro. (PMID:28713907)
• MiR-4463 expression in the aortic smooth muscle cells in the arteriosclerosis obliterans patients.MiR-4463 is a novel modulator of the vascular smooth muscle cell migration by targetting AMOT expression. (PMID:29752344)
• Downregulation of miR-4463 enhances PNUTS expression, which promotes PTEN nuclear translocation, with increased AKT phosphorylation and increased cell survival, thus providing a rationale for the anti-apoptotic role of the downregulation of miR-4463. (PMID:30244253)
• MicroRNA-4463 facilitates the development of colon cancer by suppression of the expression of PPP1R12B. (PMID:35064454)
• miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells. (PMID:35748251)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.