MIR4464

Summary

MIR4464 (microRNA 4464, HGNC:41528) is a microRNA gene on chromosome 6q15.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616109 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41528
Approved symbol	MIR4464
Name	microRNA 4464
Location	6q15
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4464
Ensembl gene	ENSG00000266760
Ensembl biotype	miRNA
Entrez	100616109
RNAcentral	URS000075A798 — miRNA, 92 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580818

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580818 — 1 exons

Exon	Start	End
ENSE00002728088	90312742	90312833

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 80.26.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	80.26	gold quality
liver	UBERON:0002107	79.27	gold quality
blood	UBERON:0000178	77.02	gold quality
right atrium auricular region	UBERON:0006631	72.47	gold quality
lymph node	UBERON:0000029	71.86	gold quality
heart left ventricle	UBERON:0002084	71.67	gold quality
amygdala	UBERON:0001876	71.21	gold quality
nucleus accumbens	UBERON:0001882	70.29	gold quality
gastrocnemius	UBERON:0001388	68.83	gold quality
body of pancreas	UBERON:0001150	68.71	gold quality
tibial artery	UBERON:0007610	68.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.91	gold quality
body of uterus	UBERON:0009853	66.66	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.54	gold quality
left ovary	UBERON:0002119	66.44	gold quality
anterior cingulate cortex	UBERON:0009835	65.82	gold quality
minor salivary gland	UBERON:0001830	65.75	gold quality
hypothalamus	UBERON:0001898	65.62	gold quality
thoracic aorta	UBERON:0001515	65.59	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.51	gold quality
transverse colon	UBERON:0001157	65.35	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.24	gold quality
ascending aorta	UBERON:0001496	65.23	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.99	gold quality
cerebellar hemisphere	UBERON:0002245	64.73	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.77	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.62	gold quality
tibial nerve	UBERON:0001323	63.04	gold quality
right ovary	UBERON:0002118	62.72	gold quality
esophagus mucosa	UBERON:0002469	62.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Intergenic risk variant rs56258221 skews the fate of naive CD4[+] T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis. (PMID:38901430)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.