MIR4465

Summary

MIR4465 (microRNA 4465, HGNC:41842) is a microRNA gene on chromosome 6q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616180 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41842
Approved symbol	MIR4465
Name	microRNA 4465
Location	6q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4465
Ensembl gene	ENSG00000264390
Ensembl biotype	miRNA
Entrez	100616180
RNAcentral	URS000075EA2C — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583434

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583434 — 1 exons

Exon	Start	End
ENSE00002713435	140683814	140683883

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 72.19.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	72.19	gold quality
calcaneal tendon	UBERON:0003701	71.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.63	gold quality
upper lobe of left lung	UBERON:0008952	68.31	gold quality
left adrenal gland	UBERON:0001234	68.00	gold quality
left ovary	UBERON:0002119	64.52	gold quality
ascending aorta	UBERON:0001496	63.93	gold quality
thyroid gland	UBERON:0002046	63.65	gold quality
left lobe of thyroid gland	UBERON:0001120	63.42	gold quality
tibial nerve	UBERON:0001323	62.97	gold quality
esophagus mucosa	UBERON:0002469	62.73	gold quality
left testis	UBERON:0004533	43.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• miR-4465 significantly inhibited the expression of PTEN, upregulated phosphorylated AKT, and thereby inhibited autophagy by activating mTOR. (PMID:30421325)
• LncRNA SDHAP1 confers paclitaxel resistance of ovarian cancer by regulating EIF4G2 expression via miR-4465. (PMID:32211849)
• HDAC7 promotes the oncogenicity of nasopharyngeal carcinoma cells by miR-4465-EphA2 signaling axis. (PMID:32376822)
• Expression level of VLDL receptor and VLDL-c levels in the malignant and benign breast tumors: The correlation with miRNA-4465 and miRNA-1297. (PMID:32711022)
• LINC00240 sponges miR-4465 to promote proliferation, migration, and invasion of hepatocellular carcinoma cells via HGF/c-MET signaling pathway. (PMID:33155201)
• MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression. (PMID:39011679)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.