MIR4466

Summary

MIR4466 (microRNA 4466, HGNC:41726) is a microRNA gene on chromosome 6q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616154 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41726
Approved symbol	MIR4466
Name	microRNA 4466
Location	6q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4466
Ensembl gene	ENSG00000271899
Ensembl biotype	miRNA
Entrez	100616154
RNAcentral	URS000075C166 — miRNA, 54 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000606121

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000606121 — 1 exons

Exon	Start	End
ENSE00003697824	156779678	156779731

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 79.23.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.23	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.38	gold quality
monocyte	CL:0000576	73.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.42	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.50	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.65	gold quality
right lobe of liver	UBERON:0001114	70.49	gold quality
right atrium auricular region	UBERON:0006631	69.45	gold quality
body of stomach	UBERON:0001161	69.04	gold quality
tibial artery	UBERON:0007610	68.99	gold quality
stomach	UBERON:0000945	68.91	gold quality
myometrium	UBERON:0001296	68.55	gold quality
skin of abdomen	UBERON:0001416	68.35	gold quality
liver	UBERON:0002107	68.04	gold quality
caudate nucleus	UBERON:0001873	68.00	gold quality
transverse colon	UBERON:0001157	67.81	gold quality
cerebellar hemisphere	UBERON:0002245	67.11	gold quality
nucleus accumbens	UBERON:0001882	66.27	gold quality
vagina	UBERON:0000996	66.06	gold quality
esophagus mucosa	UBERON:0002469	65.75	gold quality
left adrenal gland cortex	UBERON:0035825	65.54	gold quality
left ovary	UBERON:0002119	65.37	gold quality
skin of leg	UBERON:0001511	65.05	gold quality
putamen	UBERON:0001874	64.89	gold quality
left adrenal gland	UBERON:0001234	64.88	gold quality
tibial nerve	UBERON:0001323	64.53	gold quality
right frontal lobe	UBERON:0002810	64.49	gold quality
left lobe of thyroid gland	UBERON:0001120	63.54	gold quality
body of uterus	UBERON:0009853	63.06	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.